Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis
نویسندگان
چکیده
منابع مشابه
BACTERIAL CONJUNCTIVITIS IN ZAHEDAN
The objective of this study was to determine the most common type of pathogen causing conjunctivitis. Out of 495 patients who referred to the Zahedan Eye Clinic from May 22, 199 1 to October 22, 1992,296 cases were diagnosed as nonbacterial conjunctivitis. From the remaining number of cases, two patients had chlamydia and six patients had Candida albicans, while the frequency of bacterial i...
متن کاملBacterial conjunctivitis in Muc1 null mice.
PURPOSE In contrast to wild-type mice, genetically engineered Mucin1 (Muc1) null animals display a marked propensity for development of blepharitis and conjunctivitis. Molecular approaches confirmed the presence of Muc1 mRNA and protein in the conjunctival tissue of wild-type mice and identified the bacterial species in Muc1 null symptomatic mice. METHODS Muc1 null animals housed in a convent...
متن کاملMonovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection
Monoclonal antibodies (IG1, k) directed against a surface component of Plasmodium berghei sporozoites (Pb-44) confer complete protection to mice against a lethal inoculum of parasites. The degree of protection is a function of the number of parasites used in the challenge and of the antibody concentration in serum. Passive transfer of 10 micrograms of antibody per mouse abolished or profoundly ...
متن کاملAntibodies to a cell surface histone-like protein protect against Histoplasma capsulatum.
A protective role for antibodies has not previously been described for host defense against the pathogenic fungus Histoplasma capsulatum (Hc). Mouse mAb's were generated from mice immunized with Hc yeast that binds the cell surface of Hc. Administration of mAb's before Hc infection reduced fungal burden, decreased pulmonary inflammation, and prolonged survival in a murine infection model. Prote...
متن کاملAntibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge.
Pneumococcal serine-rich repeat protein (PsrP) is a putative adhesin encoded in the Streptococcus pneumoniae pathogenicity island psrP-secY2A2. Challenge of mice with serotype 4, strain TIGR4, and the isogenic mutants T4DeltapsrP and T4DeltapsrP-secY2A2 determined that PsrP was required for bacterial persistence in the lungs but not for colonization in the nasopharynx or replication in the bloo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2018
ISSN: 1552-5783
DOI: 10.1167/iovs.18-23795